Human Claudin-18.2 Full Length Protein (VLP)
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Product Specifications
Background
Specifications
This protein .
Accession Number
P56856-2
Expression Region
Met 1 - Val 261
Host
HEK293
Target
Claudin-18.2
Conjugation
Unconjugated
Tag
-
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Format
Liquid
Buffer
PBS, pH7.4
Additives
Trehalose
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*1
Host or Source
HEK293
Species
Human
Protein ID
P56856-2
Preservative
Trehalose
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