IFN-γ Antagonist 1
Product Specifications
UNSPSC Description
IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ (IFN γ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC50 value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation[1].
Target Antigen
IFNAR
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ifn-γ-antagonist-1.html
Purity
99.47
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(CCC1)C(CNC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC(CNC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CSCNC(C)=O)NC([C@@H](NC([C@@H](N)C)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
2629.04
References & Citations
[1]Seelig GF, et al. Development of a receptor peptide antagonist to human gamma-interferon and characterization of its ligand-bound conformation using transferred nuclear Overhauser effect spectroscopy. J Biol Chem. 1995 Apr 21;270(16):9241-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P4717/IFN-γ-Antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P4717/IFN-γ-Antagonist-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
158040-83-6
Available Sizes
Curated Selection
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