Thrombin from Human Plasma (Highly Pure)

<strong>Thrombin from Human Plasma (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2013691_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 U_x000D_ <strong>Molecular Weight or Concentration:</strong> ≥ 2800 NIH units/mg protein_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20° C_x000D_ <strong>Keywords:</strong> Thrombin, Human Plasma, High Activity_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Heitmeier S, Visser M, Tersteegen A, Dietze-Torres J, Glunz J, Gerdes C, Laux V, Stampfuss J, Roehrig S. Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa J Thromb Haemost. 2022 Jun;20(6):1400-1411._x000D_ 2: Li M, Tang X, Liao Z, Shen C, Cheng R, Fang M, Wang G, Li Y, Tang S, Xie L, Zhang Z, Kamau PM, Mwangi J, Lu Q, Li Y, Wang Y, MacKeigan DT, Cerenzia EG, Ni H, Lai R. Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude Blood. 2022 Nov 10;140(19):2063-2075._x000D_ 3: Zavyalova E, Golovin A, Timoshenko T, Babiy A, Pavlova G, Kopylov A. DNA aptamers for human thrombin with high anticoagulant activity demonstrate target- and species-specificity Curr Med Chem. 2012;19(30):5232-7._x000D_ 4: Aizawa P, Winge S, Karlsson G. Large-scale preparation of thrombin from human plasma Thromb Res. 2008;122(4):560-7._x000D_ 5: Karlsson G. Analysis of human alpha-thrombin by hydrophobic interaction high-performance liquid chromatography Protein Expr Purif. 2003 Jan;27(1):171-4._x000D_ 6: Prasa D, Svendsen L, St_rzebecher J. The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation Thromb Haemost. 1997 Mar;77(3):498-503._x000D_ 7: Hulshof AM, Hemker HC, Spronk HMH, Henskens YMC, Ten Cate H. Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis Int J Mol Sci. 2021 Mar 4;22(5):2590._x000D_ 8: Stief TW. Arginine inhibits serpins Clin Appl Thromb Hemost. 2007 Apr;13(2):213-8._x000D_ 9: Miller GJ, Seghatchian MJ, Walter SJ, Howarth DJ, Thompson SG, Esnouf MP, Meade TW. An association between the factor VII coagulant activity and thrombin activity induced by surface/cold exposure of normal human plasma Br J Haematol. 1986 Feb;62(2):379-84._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/8603018">10: Wuillemin WA, Mertens K, ten Cate H, Hack CE. Thrombin-mediated activation of endogenous factor XI in plasma in the presence of physiological glycosaminoglycans occurs only with high concentrations of thrombin Br J Haematol. 1996 Feb;92(2):466-72. </a>_x000D_ _x000D_ <strong>Products Related to Thrombin from Human Plasma can be found at</strong> <a href="https://moleculardepot.com/product-category/Enzymes/"> Enzymes</a>