Glycyl-L-glutamic acid

Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].

Product Specifications

CAS Number

[7412-78-4]

Product Name Alternative

H-Gly-Glu-OH; Gly-Glu

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glycyl-l-glutamic-acid.html

Purity

99.89

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(CN)=O

Molecular Formula

C7H12N2O5

Molecular Weight

204.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc Natl Acad Sci U S A. 1985 Aug;82 (15) :5213-7.|[2]Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7 (3) :229-37.