Nav1.7-IN-2

Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. IC50 value: 80 nM Target: Nav 1.7 Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM.

Product Specifications

CAS Number

[1332295-35-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nav1.7-IN-2.html

Purity

98.28

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C(NC)(=O)C1=CC=CC(NC2=NC=CC(N3CC(OC4=CC=C(F)C=C4C)C3)=N2)=C1

Molecular Formula

C22H22FN5O2

Molecular Weight

407.44

Precautions

H315, H319, H335

References & Citations

[1]Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825.