Polycarpine (hydrochloride)
Product Specifications
UNSPSC Description
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively[1].
Target Antigen
Fungal; Influenza Virus; SARS-CoV; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polycarpine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C2=C(N(C(N)=N2)C)SSC3=C(N=C(N3C)N)C4=CC=C(C=C4)OC.Cl.Cl
Molecular Weight
541.52
References & Citations
[1]Zhang J, et al. An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting M<sup>pro</sup>. Bioorg Med Chem Lett. 2024;103:129706.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N12697A/Polycarpine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N12697A/
Clinical Information
No Development Reported
CAS Number
175669-29-1
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