NS3623

NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels[1][2][3].

Product Specifications

CAS Number

[343630-41-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ns3623.html

Purity

99.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3

Molecular Formula

C15H10BrF3N6O

Molecular Weight

427.18

Precautions

H315, H319, H320

References & Citations

[1]Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52 (1) :35-41.|[2]Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6 (1) :100-6.|[3]Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46.|[4]Hansen RS, et al. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N- (4-bromo-2- (1H-tetrazol-5-yl) -phenyl) -N'- (3'-trifluoromethylphenyl) urea]. Mol Pharmacol. 2006 Oct;70 (4) :1319-29.