GPX4-IN-14
GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-14.html
Smiles
O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1
Molecular Formula
C26H39NO8Se
Molecular Weight
572.55
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Frequently Asked Questions
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