Perfluorododecanoic acid

Perfluorododecanoic acid (PFDoA) is a perfluoroalkyl substance (PFAS) found in lake trout. Perfluorododecanoic acid decreases the viability of PC12 cells. Perfluorododecanoic acid also increases reactive oxygen species (ROS), malondialdehyde (MDA) levels and reduces the mitochondrial membrane potential in PC12 cells[1][2].

Product Specifications

CAS Number

[307-55-1]

Product Name Alternative

PFDoA

UNSPSC

12352211

Hazard Statement

H302+H332, H351, H360, H362, H372

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Purity

Solubility

DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C(=O)(C(C(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O

Molecular Formula

C12HF23O2

Molecular Weight

614.10

Precautions

H302+H332, H351, H360, H362, H372

References & Citations

[1]Liu Y, et al. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquat Toxicol. 2008 Sep 29;89 (4) :242-50. |[2]Furdui VI, et al. Spatial distribution of perfluoroalkyl contaminants in lake trout from the Great Lakes. Environ Sci Technol. 2007 Mar 1;41 (5) :1554-9.