SHEN26
Product Specifications
UNSPSC Description
SHEN26 (ATY014) is a potent and orally active RdRp inhibitor, with an IC50 for SARS-CoV-2 is 1.36 μM. SHEN26 is a 5’-cyclohexanecarboxylate derivative of GS-441524 (HY-103586). SHEN26 inhibits viral nucleic acid synthesis to achieve antiviral effects. SHEN26 can be used for the research of
coronavirus disease 2019 (COVID-19)[1][2].
Target Antigen
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/shen26.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CCCCC1)OC[C@@H]2[C@@H](O)[C@@H](O)[C@@](C3=CC=C4N3N=CN=C4N)(C#N)O2
Molecular Weight
401.42
References & Citations
[1]Chen Q, et al. Optimized Kilogram-Scale Synthesis and Impurity Identification of SHEN26 (ATV014) for Treating COVID-19. Organic Process Research & Development. 2023 Nov 20. |[2]Ji X, et al. Research and development of Chinese anti-COVID-19 drugs. Acta Pharm Sin B. 2022 Dec;12(12):4271-4286.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155488/SHEN26-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155488/SHEN26-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2691076-98-7
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
