Thymidine 5′-diphosphate (sodium)

Thymidine 5′-diphosphate (dTDP) sodium is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate sodium is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate sodium is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP) . TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2].

Product Specifications

CAS Number

[108322-12-9]

Product Name Alternative

DTDP (sodium)

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thymidine-5-diphosphate-sodium.html

Purity

99.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O=C(N1)N([C@H]2C[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)C=C(C)C1=O.[Na].[x]

Molecular Formula

C10H16N2O11P2.xNa

References & Citations

[1]Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20 (10) :1286-305. |[2]Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26 (11) :2225-30.