Anti-Hu CD37 Purified
CD37 is a 40-64 kDa tetraspanin family glycoprotein, which forms complexes in the B cell membrane with MHC class II, CD53, CD81, and CD82. It is expressed highly on mature B cells and neoplastic B cells, but it is lost on plasma cells, as well as on pro-B cells. Lower expression was detected on monocytes, macrophages, and dendritic cells.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Lymphomatous lymph node cells
Target Antigen
CD37
Clone
MB-1
Applications
FC (QC tested), IP, IHC-F
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Link MP, Bindl J, Meeker TC, Carswell C, Doss CA, Warnke RA, Levy R: A unique antigen on mature B cells defined by a monoclonal antibody. J Immunol. 1986 Nov 1;137 (9) :3013-8., URL: https://pubmed.ncbi.nlm.nih.gov/3489782/, *Press OW, Eary JF, Badger CC, Martin PJ, Appelbaum FR, Levy R, Miller R, Brown S, Nelp WB, Krohn KA: Treatment of refractory non-Hodgkin's lymphoma with radiolabeled MB-1 (anti-CD37) antibody. J Clin Oncol. 1989 Aug;7 (8) :1027-38., URL: https://pubmed.ncbi.nlm.nih.gov/2666588/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody MB-1 recognizes an extracellular epitope of CD37, a tetraspanin family transmembrane glycoprotein.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG1 kappa
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