Pafenolol

Pafenolol is a selectively oral-active β1 adrenergic receptor (β1-adrenergic receptor) antagonist that effectively lowers blood pressure. Pharmacokinetic studies in rats indicate that the absorption of Pafenolol is influenced by gastrointestinal contents, with food intake reducing the bioavailability of Pafenolol in rats. Pafenolol can be used in research related to cardiovascular diseases and asthma[1].

Product Specifications

CAS Number

[75949-61-0]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pafenolol.html

Smiles

CC(C)NC(NCCC1=CC=C(C=C1)OCC(O)CNC(C)C)=O

Molecular Formula

C18H31N3O3

Molecular Weight

337.46

References & Citations

[1]Sigurdsson J A, et al. Pafenolol, a new β 1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up[J]. European journal of clinical pharmacology, 1984, 26: 549-553.