Glutaminyl Cyclase Inhibitor 6

Glutaminyl Cyclase Inhibitor 6 (compound BI-43) is a secretory glutaminyl cyclase (sQC) and golgi-resident glutaminyl cyclase (gQC) inhibitor with IC50 values of 0.012 0.040 µM, respectively. Glutaminyl Cyclase Inhibitor 6 has the potential for the research of Parkinson’s disease[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glutaminyl-cyclase-inhibitor-6.html

Smiles

O=C(/C1=C\C2=CC3=C(C=C2)NC=N3)NC4=C1C(OC5CCN(CC5)C(C6=CC=NC=C6)=O)=CC=C4

Molecular Formula

C27H23N5O3

Molecular Weight

465.50

References & Citations

[1]Mou J, et al. X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J Med Chem. 2024 May 31.