L-Azidohomoalanine (hydrochloride)

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[942518-29-8]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-azidohomoalanine-hydrochloride.html

Purity

99.76

Solubility

H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl

Molecular Formula

C4H9ClN4O2

Molecular Weight

180.59

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl-Chain Linkers

Citation 01

Cell Biosci. 2022 Dec 21;12 (1) :206.|Nat Commun. 2024 Jun 28;15 (1) :5481.|Redox Biol. 2022 Jun:52:102284.|Microbiol Spectr. 2021 Dec 22;9 (3) :e0109421.