Citreoviridin

Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner[1]. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells[2].

Product Specifications

CAS Number

[25425-12-1]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Na+/K+ ATPase

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/citreoviridin.html

Purity

99.65

Solubility

Methanol : 10 mg/mL (ultrasonic; warming)

Smiles

CC(/C=C/C=C/C=C/C(O1)=C(C(OC)=CC1=O)C)=C\[C@]2([C@H](O)[C@]([C@H](O2)C)(O)C)C

Molecular Formula

C23H30O6

Molecular Weight

402.48

Precautions

H301

References & Citations

[1]Datta SC, et al. Effect of citreoviridin, a mycotoxin from Penicillium citreoviride, on kinetic constants of acetylcholinesterase and ATPase in synaptosomes and microsomes from rat brain. Toxicon. 1981;19 (4) :555-62.|[2]Hou H, et al. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells. Environ Toxicol Pharmacol. 2014 Mar;37 (2) :828-36.