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Dibenamine (hydrochloride)

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].

Product Specifications

CAS Number

55-43-6

Product Name Alternative

N-​ (2-​Chloroethyl) ​dibenzylamine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dibenamine-hydrochloride.html

Purity

99.32

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl

Molecular Formula

C16H19Cl2N

Molecular Weight

296.23

Precautions

H302, H315, H319, H335

References & Citations

[1]R W SCHAYER, et al. Effect of dibenamine (N- (2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.J Biol Chem. 1953 May;202 (1) :39-43.|[2]H M Maling, et al. Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N- (2-chloroethyl) dibenzylamine) . Biochem Pharmacol. 1974 May 15;23 (10) :1479-91.|[3]K Araki, et al. Pharmacological studies on supersensitization. VII. Inhibitory effect of dibenamine on cocaine-induced supersensitivity of isolated vas deferens of guinea pig. J Pharmacobiodyn. 1982 Oct;5 (10) :789-95.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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