Nevadensin (Standard)

Nevadensin (Standard) (Lysionotin (Standard) ) is the analytical standard of Nevadensin (HY-N1377) . This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM) . Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.

Product Specifications

CAS Number

[10176-66-6]

Product Name Alternative

Lysionotin (Standard)

UNSPSC

12352005

Target

Apoptosis; Bacterial; Carboxylesterase (CES) ; DNA/RNA Synthesis; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nevadensin-standard.html

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(O)=C(OC)C(O)=C13

Molecular Formula

C18H16O7

Molecular Weight

344.32

References & Citations

[1]Ya-Qiao Wang, et al. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1. Int J Biol Macromol. 2018 Dec;120 (Pt B) :1944-1954.|[2]Caijuan Liang, et al. Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:69-79.