SHLP2

SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease[1][2].

Product Specifications

CAS Number

[1191923-93-9]

Product Name Alternative

Small humanin-like peptide 2

UNSPSC

12352209

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Peptides

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/shlp2.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N6[C@@H](CCC6)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

Molecular Formula

C142H214N36O35S

Molecular Weight

3017.50

References & Citations

[1]Nashine S, et al. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9 (5) : 1102.|[2]Kim, S. J., et al., (2024) . A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Molecular psychiatry, 29 (2), 505–517. |[3]Kim, S. K., et al., (2023) . Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nature communications, 14 (1), 4321.