L-AP4 (monohydrate)
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
Product Specifications
CAS Number
[2247534-79-6]
Product Name Alternative
L-APB (monohydrate)
UNSPSC
12352211
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-ap4-monohydrate.html
Purity
99.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](N)CCP(O)(O)=O.O
Molecular Formula
C4H12NO6P
Molecular Weight
201.11
References & Citations
[1]Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61 (5) :1969-1989.|[2]Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312 (1) :120-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR6; mGluR7; mGluR8
Available Sizes
Curated Selection
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