Pellitorine (Standard)

Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097) . Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4) . Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

Product Specifications

CAS Number

[18836-52-7]

UNSPSC

12352211

Target

Amyloid-β; Bacterial; Dihydroorotate Dehydrogenase; Ferroptosis; Glutathione Peroxidase; Heme Oxygenase (HO) ; Insecticide; Keap1-Nrf2; NF-κB; PAI-1; Proton Pump; Reference Standards; Thrombin; Toll-like Receptor (TLR) ; TRP Channel

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pellitorine-standard.html

Smiles

CC(C)CNC(/C=C/C=C/CCCCC)=O

Molecular Formula

C14H25NO

Molecular Weight

223.35

References & Citations

[1]Ee GC, et al. Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum. Molecules. 2010;15(4):2398-2404.