MTOR inhibitor-23

MTOR inhibitor-23 (compound DHM25) is a selective, competitive, irreversible and covalent inhibitor of mTOR. mTOR inhibitor-23 has the mechanism of inhibition occurs mainly through its capacity to covalently interact with a nucleophilic amino acid inside the ATP pocket. mTOR inhibitor-23 exerts potent antitumor activity against triple-negative breast tumor cell lines[1].

Product Specifications

CAS Number

[1685280-21-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtor-inhibitor-23.html

Smiles

BrC(C=C1)=CC=C1C2OC3=C(Br)C=C(Br)C=C3C=C2[N+]([O-])=O

Molecular Formula

C15H8Br3NO3

Molecular Weight

489.94

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Amélie Fouqué, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58 (16) :6559-73.