SDX-7539
SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2) . SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice[1].
Product Specifications
CAS Number
1631953-52-0
UNSPSC
12352005
Target
MetAP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sdx-7539.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]1([C@@H]([C@@H](CC[C@@]12OC2)OC(N[C@@H]3CC[C@@H](N)CC3)=O)OC)[C@]4(O[C@@H]4C/C=C(C)\C)C
Molecular Formula
C23H38N2O5
Molecular Weight
422.56
References & Citations
[1]Cornelius P., et al., Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity, 2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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