RI-2
RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
Product Specifications
CAS Number
[1417162-36-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RAD51
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RI-2.html
Purity
99.90
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O
Molecular Formula
C21H18Cl2N2O4
Molecular Weight
433.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Budke B, et al. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem. 2013 Jan 10;56 (1) :254-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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