Dusquetide

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR) . Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

Product Specifications

CAS Number

[931395-42-5]

Product Name Alternative

SGX942

UNSPSC

12352209

Target

Bacterial; p62

Type

Peptides

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dusquetide.html

Purity

99.96

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

C[C@@H](C(N)=O)NC([C@H]1N(C([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)CCC1)=O

Molecular Formula

C25H47N9O5

Molecular Weight

553.70

References & Citations

[1]Kudrimoti M, et al. Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study. J Biotechnol. 2016 Dec 10;239:115-125.