Recombinant Filaggrin Antibody
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 2-4 µg/mL
UniProt
P20930
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 198-288 was used as the immunogen for the recombinant Filaggrin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
FLG/3909R
Type
Recombinant
Applications
WB
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant Filaggrin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant Filaggrin antibody is available for research use only.
Storage Conditions
Aliquot the recombinant Filaggrin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Filaggrin antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
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