Fotemustine
Fotemustine is a DNA-alkylating agent, with antitumor activity.
Product Specifications
CAS Number
92118-27-9
Product Name Alternative
S10036
UNSPSC
12352211
Hazard Statement
H351
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Fotemustine.html
Purity
91.94
Solubility
DMSO : ≥ 3.2 mg/mL
Smiles
CC(P(OCC)(OCC)=O)NC(N(CCCl)N=O)=O
Molecular Formula
C9H19ClN3O5P
Molecular Weight
315.69
Precautions
H351
References & Citations
[1]Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17 (4) :715-24.|[2]Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13 (2) :141-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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