Fotemustine

Fotemustine is a DNA-alkylating agent, with antitumor activity.

Product Specifications

CAS Number

[92118-27-9]

Product Name Alternative

S10036

UNSPSC

12352211

Hazard Statement

H351

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Fotemustine.html

Purity

91.94

Solubility

DMSO : ≥ 3.2 mg/mL

Smiles

CC(P(OCC)(OCC)=O)NC(N(CCCl)N=O)=O

Molecular Formula

C9H19ClN3O5P

Molecular Weight

315.69

Precautions

H351

References & Citations

[1]Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17 (4) :715-24.|[2]Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13 (2) :141-7.