AKR1B1 Antibody / Aldose reductase
AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P15121
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length AKR1B1 protein was used as the immunogen for the AKR1B1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RAKR1B1/7295
Type
Recombinant
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the AKR1B1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AKR1B1 antibody is available for research use only.
Storage Conditions
Aliquot the AKR1B1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the AKR1B1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human HEK293 cell lysate with AKR1B1 antibody (clone rAKR1B1/7295) . Predicted molecular weight ~36 kDa.
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