Chromogranin A Antibody
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P10645
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 23-165 was used as the immunogen for the Chromogranin A antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CHGA/4223
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Chromogranin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Chromogranin A antibody is available for research use only.
Storage Conditions
Aliquot the Chromogranin A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Chromogranin A antibody should be determined by the researcher.
Location
Finely granular cytoplasmic
Image Legend
SDS-PAGE analysis of purified, BSA-free Chromogranin A antibody (clone CHGA/4223) as confirmation of integrity and purity.
Frequently Asked Questions
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