IRF9 Antibody / Interferon regulatory factor 9
Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q00978
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human IRF9 protein was used as the immunogen for the IRF9 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-IRF9-2F8
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IRF9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IRF9 antibody is available for research use only.
Storage Conditions
Aliquot the IRF9 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IRF9 antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using IRF9 antibody (green, clone PCRP-IRF9-2F8) and phalloidin (red) .
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