IDH1 Antibody / Isocitrate Dehydrogenase (R132H mutant)
IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
O75874
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 281-414 was used as the immunogen for the IDH1 R132H antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
IDH1/6806R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the IDH1 R132H antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IDH1 R132H antibody is available for research use only.
Storage Conditions
Aliquot the IDH1 R132H antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the IDH1 R132H antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
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