Recombinant GATA3 Antibody
GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 1-2 µg/mL
UniProt
P23771
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A conserved peptide between the GATA trans-activation and DNA-binding domain was used as the immunogen for the recombinant GATA3 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
GATA3/4550R
Type
Recombinant
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant GATA3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant GATA3 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant GATA3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant GATA3 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
2- (2,5-Dichlorophenyl) pyrrolidine hydrochloride
2- (2,5-Dichlorophenyl) pyrrolidine hydrochloride
