H-Trp-Phe-Tyr-Ser (PO3H2) -Pro-Arg-pNA
H-Trp-Phe-Tyr-Ser (PO3H2) -Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins[1][2].
Product Specifications
CAS Number
202739-41-1
UNSPSC
12352209
Target
Fluorescent Dye
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/h-trp-phe-tyr-ser-po3h2-pro-arg-pna.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](COP(O)(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O)NC([C@H](CC4=CC=CC=C4)NC([C@@H](N)CC5=CNC6=CC=CC=C56)=O)=O
Molecular Formula
C49H59N12O13P
Molecular Weight
1055.04
References & Citations
[1]M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278 (5345) :1957-60.|[2]Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54 (11) :3854-65.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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