Recombinant Cystic Fibrosis Transmembrane Regulator Antibody / CFTR
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR) . CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP) -activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 0.5-2 µg/mL
UniProt
P13569
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 258-385 was used as the immunogen for the recombinant Cystic Fibrosis Transmembrane Regulator antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RCFTR/6476
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant Cystic Fibrosis Transmembrane Regulator antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant Cystic Fibrosis Transmembrane Regulator antibody is available for research use only.
Storage Conditions
Aliquot the recombinant Cystic Fibrosis Transmembrane Regulator antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Cystic Fibrosis Transmembrane Regulator antibody should be determined by the researcher.
Location
Cell Surface, Cytoplasm
Image Legend
Frequently Asked Questions
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