HSP60/GROEL Antibody
Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60) . Its epitope is localized between aa 383-447 of human hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsp s), more appropriately called as stress response proteins (srp s) . hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone HSPD1/6498R, unlike clone LK2, recognizes only the mammalian (not bacterial) hsp60 and is useful in distinguishing hsp60 from mammals and bacteria.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P10809
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
HSPD1/6498R
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the HSP60/GROEL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HSP60/GROEL antibody is available for research use only.
Storage Conditions
Aliquot the HSP60/GROEL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the HSP60/GROEL antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human 1) Hep2 and 2) HeLa cell lysate using HSP60/GROEL antibody (clone HSPD1/6498R) . Predicted molecular weight: ~60 kDa.
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