TCF1 alpha Antibody / LEF1 / Lymphoid enhancer-binding factor 1
Lymphoid Enhancing Factor 1 (LEF1), also called T cell-specific transcription factor 1-alpha (TCF1 alpha) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9UJU2
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 100-200 was used as the immunogen for the TCF1 alpha antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
LEF1/422R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TCF1 alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TCF1 alpha antibody is available for research use only.
Storage Conditions
Aliquot the TCF1 alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TCF1 alpha antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human lymph node cells (nuclear staining of non-germinal center) using TCF1 alpha antibody (clone LEF1/422R) at 2ug/ml.
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