ZMYM3 Antibody
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZMYM3 (zinc finger MYM-type protein 3), also known as ZNF261 (zinc finger protein 261), XFIM, DXS6673E or MYM, is a 1,370 amino acid nuclear protein that contains nine MYM-type zinc fingers. Expressed in a variety of tissues, including heart, muscle and brain, ZMYM3 is thought to function as part of a histone deacetylase-containing complex that contains other proteins, such as HDAC1 and HDAC2, and may play a role in gene silencing through the modification of chromatin structure. Defects in the gene encoding ZMYM3 that lead to chromosomal translocations may be a cause of X-linked mental retardation. Two isoforms of ZMYM3 exist due to alternative splicing events.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q14202
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human ZMYM3 protein was used as the immunogen for the ZMYM3 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-ZMYM3-2F10
Applications
FACS, IF, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ZMYM3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ZMYM3 antibody is available for research use only.
Storage Conditions
Aliquot the ZMYM3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ZMYM3 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using ZMYM3 antibody (green, clone PCRP-ZMYM3-2F10) and phalloidin (red) .
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