SMARCC1 Antibody / BAF155
The SWI/SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF1 or SNF2) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI/SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor) .
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q92922
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human SWI/SNF complex subunit SMARCC1 protein was used as the immunogen for the SMARCC1 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-SMARCC1-1F1
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the SMARCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SMARCC1 antibody is available for research use only.
Storage Conditions
Aliquot the SMARCC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the SMARCC1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using SMARCC1 antibody (green, clone PCRP-SMARCC1-1F1) and phalloidin (red) .
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