CD5 Ligand Antibody / CD5L

CD5L (CD5 molecule-like), also known as API6, PRO229, Sp or SP-ALPHA, is a 347 amino acid secreted protein that belongs to the scavenger receptor cysteine-rich (SRCR) family of leukocyte regulating proteins. Expressed in bone marrow, spleen, thymus, lymph node and fetal liver, CD5L is thought to be involved in regulating the immune system via binding to peripheral monocytes and mediating their activation and overall survival. CD5L has three cysteine-rich domains and, in addition to its role in the immune system, may function to inhibit apoptosis and promote macrophage survival.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

O43866

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 269-366 was used as the immunogen for the CD5 Ligand antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

CD5L/4420

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the CD5 Ligand antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This CD5 Ligand antibody is available for research use only.

Storage Conditions

Aliquot the CD5 Ligand antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the CD5 Ligand antibody should be determined by the researcher.

Location

Secreted

Image Legend

IHC staining of FFPE human tonsil tissue with CD5 Ligand antibody (clone CD5L/4420) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.