NOC4L Antibody
Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q9BVI4
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human NOC4L protein was used as the immunogen for the NOC4L antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PCRP-NOC4L-1E3
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the NOC4L antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NOC4L antibody is available for research use only.
Storage Conditions
Aliquot the NOC4L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the NOC4L antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using NOC4L antibody (green, clone PCRP-NOC4L-1E3) and phalloidin (red) .
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