C-terminal-binding protein 2 Antibody / CTBP2
The gene CTBP2 (C-terminal binding protein 2) encodes a member of the CtBP-family. The gene is mapped to human chromosome 21q21.3. It is found to be expressed ubiquitously, with higher expression in the heart, skeletal muscle, and pancreas. The gene CTBP2 (C-terminal binding protein 2) encodes a protein that functions as a transcriptional co-repressor of several tumor suppressor genes resulting in enhanced cancer cell migration and invasion. Its expression is found to be upregulated in hepatocellular carcinoma (HCC) . It may be a potential prognostic marker for post liver resection HCC. It is involved in several types of tumor initiation, progression and response to therapy. It is found to interact with the C-terminal region of adenovirus type 2/5 E1A protein, a region that negatively regulates tumorigenicity and the extent of oncogenic transformation.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
P56545
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human CTBP2/C-terminal-binding protein 2 protein was used as the immunogen for the C-terminal-binding protein 2 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-CTBP2-2D11
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the C-terminal-binding protein 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This C-terminal-binding protein 2 antibody is available for research use only.
Storage Conditions
Aliquot the C-terminal-binding protein 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the C-terminal-binding protein 2 antibody should be determined by the researcher.
Location
Nucleus, Cell junction
Image Legend
Immunofluorescent staining of human MCF-7 cells using C-terminal-binding protein 2 antibody (green, clone PCRP-CTBP2-2D11) and phalloidin (red) .
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