What is the catalog number for NACC1 Antibody / Nac1 / BTBD14B?

The catalog number for NACC1 Antibody / Nac1 / BTBD14B is V9183SAF-100UG.

What sizes are available for NACC1 Antibody / Nac1 / BTBD14B?

NACC1 Antibody / Nac1 / BTBD14B is available in the following size(s): 100 µg.

Is NACC1 Antibody / Nac1 / BTBD14B in stock?

NACC1 Antibody / Nac1 / BTBD14B is currently made to order / not held in immediate stock. Contact us for lead time.

NACC1 Antibody / Nac1 / BTBD14B

The BTB (broad-complex, tramtrack and bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homo-oligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.

Product Specifications

CAS Number

9007-83-4

Specifications

Flow cytometry: 1-2ug/million cells

UniProt

Q96RE7

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full-length human NACC1 protein was used as the immunogen for the NACC1 antibody.

Clonality

Monoclonal

Isotype

IgG2a

Clone

PCRP-NACC1-1A8

Applications

FACS

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the NACC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This NACC1 antibody is available for research use only.

Storage Conditions

Aliquot the NACC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the NACC1 antibody should be determined by the researcher.

Location

Nucleus, Cytoplasm

Image Legend

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using NACC1 antibody (clone PCRP-NACC1-1A8) . These results demonstrate the foremost specificity of the PCRP-NACC1-1A8 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.