TOM1L1 Antibody

Tom1 (target of Myb 1) is a 492 amino acid cytoplasmic protein that belongs to the Tom1 family. Widely expressed with highest expression in heart, liver, placenta and skeletal muscle, Tom1 is thought to be involved in intracellular trafficking and may be associated with the translocation of ubiquitinated proteins to early endosomes for degradation. Tom1 contains one GAT domain and one VHS domain through which it interacts and complexes with proteins such as Tollip and endofin (also known as SARA) . These interactions recruit Tom1 to the endosome, allowing it to participate in the endosomal trafficking of ubiquitin-tagged proteins.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 2-4 µg/mL

UniProt

O75674

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full-length human TOM1L1 protein was used as the immunogen for the TOM1L1 antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

TOM1L1/4690

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the TOM1L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This TOM1L1 antibody is available for research use only.

Storage Conditions

Aliquot the TOM1L1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the TOM1L1 antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

IHC staining of FFPE human kidney tissue with TOM1L1 antibody (clone TOM1L1/4690) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.