UPK1A Antibody / Uroplakin 1A

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA-free format for coating)

UniProt

O00322

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 114-173 was used as the immunogen for the UPK1A antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

UPK1A/2923

Applications

ELISA

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the UPK1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This UPK1A antibody is available for research use only.

Storage Conditions

Aliquot the UPK1A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the UPK1A antibody should be determined by the researcher.

Location

Cell Surface

Image Legend

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using UPK1A antibody (clone UPK1A/2923) . These results demonstrate the foremost specificity of the UPK1A/2923 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.