Hepatocyte Antibody
Hepatocyte Specific Antigen, also called Hepatocyte Paraffin 1 or Hep Par 1, localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCCs occur primarily in the stomach, but they are also found in many other organs. The Hepatocyte Specific Antigen may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller tumor size and longer patient survival. Occasionally, Hepatocyte Specific Antigen is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Not Known
Host
Mouse
Reactivity
Human
Immunogen
Extract of a formalin-fixed rejected-allograft of human liver was used a the immunogen for this Hepatocyte antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM582
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Hepatocyte antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Hepatocyte antibody is available for research use only.
Storage Conditions
Store the Hepatocyte antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Finely granular cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with Hepatocyte antibody (SPM582) .
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