HOAT-IN-1

HOAT-IN-1 (compound 5) is a mechanical inhibitor of human ornithine aminotransferase (hOAT) . hOAT-IN-1 as a time-dependent inhibitor can form tightly bound PLP inhibitor adduct with hOAT. hOAT-IN-1 can result IN tight occupation of the active site of hOAT. hOAT-IN-1 can be used in the study of lung cell carcinoma [1].

Product Specifications

CAS Number

[3057092-65-3]

UNSPSC

12352211

Target

Aminotransferases (Transaminases)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hoat-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C[C@H](N)CC(F)(F)C1)O

Molecular Formula

C7H9F2NO2

Molecular Weight

177.15

References & Citations

[1]Devitt A N, et al. Design, Synthesis, and Mechanistic Studies of (R) -3-Amino-5, 5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase[J]. ACS Chemical Biology, 2024.