Mucin-1 Antibody
Mucin-1 is a 265-400kDa glycoprotein. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. . The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. MUC1 may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P15941
Host
Mouse
Reactivity
Human
Immunogen
Delipidated extract of human milk fat globule membranes was used as the immunogen for this Mucin-1 antibody.
Clonality
Monoclonal
Isotype
IgG2a λ
Clone
SPM533
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Mucin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Mucin-1 antibody is available for research use only.
Storage Conditions
Store the Mucin-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic & cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human breast carcinoma stained with Mucin-1 antibody (clone SPM533) .
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