PSA Antibody
Recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA) . This mAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT) . A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P07288
Host
Mouse
Reactivity
Human
Immunogen
Prostate specific antigen from human sperm plasma was used as the immunogen for this PSA antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM352
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PSA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PSA antibody is available for research use only.
Storage Conditions
Store the PSA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human prostate carcinoma stained with PSA antibody (SPM352) .
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