IgM Antibody
Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01871, P20769
Host
Mouse
Reactivity
Human
Immunogen
Recombinant heavy chain of human IgM was used as the immunogen for this IgM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM557
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the IgM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This IgM antibody is available for research use only.
Storage Conditions
Store the IgM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasm, Cell Surface and Secreted
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with IgM antibody (SPM557) .
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