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Secretory Component Antibody / ECM1

This mAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

Q16610

Host

Mouse

Reactivity

Human

Immunogen

Secretory Component protein isolated from human colostrum was used as the immunogen for this Secretory Component antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

SPM217

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the Secretory Component antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Secretory Component antibody is available for research use only.

Storage Conditions

Store the Secretory Component antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Location

Cell surface and cytoplasmic

Image Legend

IHC: Formalin-fixed, paraffin-embedded human colon carcinoma stained with IgA Secretory Component antibody (SPM217) .

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